How GLP-1 Agonists Work and Why Everyone’s Talking About Them

March 20, 2025 0 Comments Carrie Thompson, NP-C
GLP-1 agonists for weight loss and metabolic health with Semaglutide and Tirzepatide.
March 20th, 2025 0 Comments

GLP-1 agonists like Semaglutide and Tirzepatide are bringing new hope to those on a weight loss journey, offering a gentle, science-backed approach to achieving lasting results. While most people tolerate them well, some may notice mild changes, such as a slight reduction in facial volume. If this happens, know that you’re not alone—and that there are ways to address these changes. At Evexias Medical in Denver, CO, our compassionate providers are here to guide you every step of the way. With a personalized approach, we’ll help you find a plan that fits your body, your goals, and your life.

Losing weight can be a deeply personal journey—one that often comes with its fair share of challenges and frustrations. If you’ve ever felt stuck despite your best efforts, you’re not alone. The good news is that medical advancements have opened new doors, offering hope and real solutions for those struggling with weight management.

GLP-1 agonists, like Semaglutide and Tirzepatide, work gently with your body’s natural processes to support sustainable weight loss and improve overall health. Unlike restrictive diets or exhausting workout routines that can feel overwhelming and difficult to maintain, these treatments help regulate appetite, slow digestion, and encourage fat metabolism in a way that feels more natural and achievable.

If you’ve been searching for a way to lose weight that truly works with your body—not against it—you may find comfort in knowing that you’re not alone in this journey. Let’s take a closer look at how these treatments can help you regain control and feel like yourself again.

What Are GLP-1 Agonists?

GLP-1 (glucagon-like peptide 1) is a hormone your body naturally produces to regulate blood sugar, control appetite, and support fat metabolism. Think of it as your body’s built-in weight management system!

GLP-1 agonists, like Semaglutide and Tirzepatide, are synthetic versions of this hormone, designed to amplify its effects. They’re used in peptide therapy to enhance the way your body processes food, making weight loss easier and more effective.

Here’s how they work their magic:

  • Appetite Control: These peptides send signals to your brain that say, “Hey, I’m full!”, helping you feel satisfied longer and reducing cravings.
  • Slower Digestion: Food moves through your stomach more slowly, keeping you fuller for longer and preventing those “I need a snack” moments.
  • Better Fat Metabolism: By improving how your body handles glucose and reducing fat storage, these treatments help your body burn fat instead of holding onto it.

Because of these incredible effects, GLP-1 agonists have become one of the most effective, science-backed weight loss treatments available today.

Why GLP-1 Agonists Are So Popular

The hype around GLP-1 agonists isn’t just marketing—these treatments have been clinically proven to help people lose weight and improve their metabolic health. Here’s why so many people are turning to them:

  1. Sustainable Weight Loss
    Unlike trendy diets or extreme exercise regimens that only provide short-term results, GLP-1 agonists support gradual, steady weight loss. Because they work with your body’s natural hormones, they make it easier to maintain your results in the long run.
  2. Better Blood Sugar Control
    These peptides also play a key role in insulin regulation, which is crucial for preventing type 2 diabetes and managing weight-related health issues. If you’ve struggled with blood sugar imbalances, this treatment can help stabilize your levels while also promoting weight loss.
  3. Minimal Side Effects
    Most people tolerate GLP-1 agonists really well. Side effects, if they do occur, are usually mild—like temporary nausea or stomach discomfort—and they often fade as your body adjusts to the medication.
  4. Overall Metabolic Health Benefits
    GLP-1 agonists don’t just help with weight loss—they can also improve your energy levels, digestion, and fat metabolism, making you feel better overall. It’s a win-win for both weight loss and long-term health!

What to Expect During GLP-1 Agonist Treatment

Starting GLP-1 agonist therapy is pretty simple. Here’s how the process works:

  • Consultation: Your journey starts with a one-on-one consultation where your provider assesses your health and weight loss goals.
  • Personalized Treatment Plan: Based on your needs, your provider will create a plan tailored to your unique health profile.
  • Injection Process: These medications are self-administered injections (don’t worry—they’re tiny and easy to use!).
  • Ongoing Support: Your provider will monitor your progress, adjust dosages if needed, and ensure you’re getting the best results possible.

Possible Side Effects of GLP-1 Agonists

Like any medication, GLP-1 agonists can cause some side effects, but most are mild and temporary.

Common side effects:

  • Nausea – GLP-1 agonists slow down digestion, which can cause food to stay in the stomach longer, triggering nausea. This effect usually improves over time as the body adapts to the medication. Eating smaller, more frequent meals and avoiding greasy or heavy foods can help reduce nausea.
  • Changes in digestion (constipation or diarrhoea) – Slower digestion may reduce bowel movements, leading to constipation, while changes in gut motility can sometimes result in diarrhea. Drinking plenty of water and eating fiber-rich foods can help regulate digestion. A probiotic supplement or gentle stool softener may also help balance gut health.
  • Reduced appetite – GLP-1 agonists influence hunger hormones, leading to decreased appetite and lower food intake. While this can support weight loss, it’s important to maintain balanced nutrition to prevent deficiencies. Setting reminders to eat small, nutrient-dense meals and focusing on protein intake can help ensure proper nourishment.
  • Facial volume loss – You may have heard about “Ozempic face”; as a side effect of GLP-1 agonists, though the term can be misleading because this is a possible side effect of any GLP-1 agonist – or any other cause of rapid weight loss. The rapid loss of fat in the face can cause a hollowed look to the face, wrinkles, sunken eyes, sagging jowls and changes in the size of the lips, cheeks, or chin.

If weight is lost in a more gradual way, these changes may not be as noticeable. It is the faster pace of weight loss that occurs with GLP-1 agonists that can make facial changes more obvious.

If “Ozempic face” side effects are significant, they can be treated with skincare, facial exercises, or aesthetic treatments if desired. Dermal fillers, collagen-boosting treatments, and a nutrient-rich diet may help maintain facial volume.

Less common side effects:

● Pancreatitis (Inflammation of the Pancreas) – This condition causes severe abdominal pain, nausea, and vomiting due to inflammation of the pancreas, potentially triggered by GLP-1 agonists affecting digestive enzymes. To reduce risk, avoid excessive alcohol intake, monitor for persistent stomach pain, and seek immediate medical attention if symptoms arise.
● Gastroparesis (Delayed Stomach Emptying) – Food moves too slowly or stops in the stomach, leading to bloating, nausea, and early fullness, as GLP-1 agonists naturally slow digestion. Eating smaller meals, avoiding high-fat foods, and adjusting medication dosage with a doctor’s guidance can help manage symptoms.
● Bowel Obstruction (Blocked Intestines) – A blockage in the intestines can cause severe pain, bloating, and constipation, sometimes due to slowed digestion or pre-existing conditions. Staying hydrated, eating easily digestible foods, and seeking urgent care for persistent symptoms can help prevent complications.

Maintaining Results After GLP-1 Agonist Therapy

Once you’ve reached your goal weight, you’ll want to keep those results for the long haul! Here’s how:

  • Stick to a Healthy Diet: Even after stopping the medication, eating a balanced diet helps maintain your weight loss.
  • Exercise Regularly: Moving your body—whether it’s walking, yoga, or strength training—keeps your metabolism active.
  • Stay Hydrated: Proper hydration helps with digestion and overall wellness.

Follow Up with Your Provider: Some people benefit from maintenance doses to keep their results stable. Your provider can help determine what’s right for you.

Is GLP-1 Agonist Therapy Right for You?

GLP-1 agonist therapy might be a great option if:

  • You have a BMI of 30 or higher, or a BMI of 27+ with weight-related health conditions like diabetes or high blood pressure.
  • You’ve struggled with losing weight despite making lifestyle changes.
  • You want a long-term, sustainable weight loss solution.

Your provider will work with you to determine if GLP-1 therapy is the right fit for your weight loss journey!

Aftercare Tips for GLP-1 Agonist Therapy

After your treatments, here are a few tips to help ensure you get the most out of your GLP-1 therapy:

  • Stay Consistent: Follow your treatment plan and attend any follow-up appointments to track your progress.
  • Healthy Eating and Exercise: GLP-1 agonists work best when combined with a healthy diet and regular physical activity.
  • Stay Hydrated: Drinking plenty of water can help your body process the treatment and improve overall digestion.
  • Report Any Side Effects: If you experience any concerns, like changes in facial volume or other side effects, be sure to discuss them with your provider to adjust your treatment.

Reclaim Your Weight Loss Journey with GLP-1 Agonist Weight Loss at Evexias Medical in Denver, CO

At Evexias Medical in Denver, CO, we are committed to helping you achieve your weight loss goals with personalized GLP-1 agonist therapy. Our expert team will work closely with you to create a tailored treatment plan that not only promotes sustainable weight loss but also ensures your overall health and well-being.

With the support of GLP-1 treatments like Semaglutide and Tirzepatide, combined with our ongoing care, you can confidently reclaim your weight loss journey and enjoy lasting results. If you’re ready to take the first step toward a healthier you, schedule a consultation with us today and begin your transformation!

Frequently Asked Questions About GLP-1 Agonists for Weight Loss

  1. How long does it take to see results from GLP-1 agonist therapy?
    You may start noticing a decrease in appetite and early weight loss within the first few weeks. Full results typically take several months to achieve.
  2. Is GLP-1 agonist therapy safe?
    Yes, GLP-1 agonists are generally safe when used as prescribed under the guidance of a trained healthcare professional. Side effects are typically mild and temporary.
  3. How many treatments will I need?
    Most patients require several treatments to achieve their desired results. Your provider will create a personalized plan based on your health and weight loss goals.
  4. Can GLP-1 therapy be used alongside other weight loss methods?
    Yes, GLP-1 therapy can be combined with diet and exercise for optimal results. Your provider will guide you on how to integrate it into your weight loss plan.
  5. Will I regain weight after stopping treatment?
    With a healthy lifestyle, the weight you lose should stay off. However, some individuals may need occasional maintenance treatments to continue benefiting from GLP-1 therapy.